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KMID : 0043319990220030313
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Archives of Pharmacal Research
1999 Volume.22 No. 3 p.313 ~ p.316
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Inhibition of Mouse Ear Edema by Steroidal and Triterpenoid Saponins
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Kim Sung-Yong
Son Kun-Ho
Chang Hyun-Wook
Kang Sam-Sik
Kim Hyun-Pyo
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Abstract
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Certain steroids and triterpenoids isolated from diverse plant families were known to posses anti-inflammatory activity. In the course of finding new anti-inflammatory natural products, some steroidal and triterpenoid saponins were isolated and evaluated for their anti-inflammatory activity using in vivo mouse ear edema test. At the oral dose of 100 mg/kg, several steroidal saponins and triterpenoid saponins such as hederagenin glycosides showed significant inhibition of ear edema (20∼37% inhibition), though less potent than indomethacin and hydrocortisone.
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KEYWORD
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Steroidal saponin, Triterpenoid saponin, Hederagenin, Anti-inflammation, Ear edema, Medicinal plant
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